Design and Development of Fenoprofen Calcium Tablets for Colone Targeting

The objective of the present investigation was to development of enteric coated tablet of fenoprofen calcium. The study results showed that disintegration time and dissolution studies of inner core tablet found to be in the range of 7.15 to 13.34 min and 95.92±0.011% at 30 min. The press coat tablets at optimum concentrations of hydroxy propyl cellulose (200 mg) and ethyl cellulose N-22 (200 mg) showed the % drug release 83.53±0.014% at 12 h, % cumulative drug release of enteric coated tablet of optimized batch FT9 showed 76.08±0.045 at 12h, it indicated that drug release at sustained manner. The presence of EC in hydrophilic compression coat retarded the initial swelling of the coat in weakly acidic pH, but in alkaline pH, enhancement in drug release rate was observed due to the dissolution of EC from the coat with time resulting in a porous coat structure, resulted in a faster and controlled drug release in the target area. The present studies, it was concluded that an optimized formulation successfully delaying drug release for a programmable period of time to attain colon targeted delivery.