Chemotherapy and hemostasis disorders
Cancer patients are at risk of developing arterial and venous thrombosis during chemotherapy (CT) and after its cessation. A prothrombotic risk may arise via pathogenetic pathways such as activation of external and internal coagulation pathways, decreased anticoagulant levels, platelet activation, fibrinolysis blockade, etc. Chemotherapeutic agents exert direct cytotoxicity, as well as indirectly suppress cellular processes necessary for tumor cell proliferation. CT-related cytotoxicity act on both tumor and healthy body cells. Available targeted drugs with improved selectivity for tumor cells are also associated with thrombosis risk. Low molecular weight heparins, which effectively reduce the risk of venous thromboembolism, have not yet been officially recommended for routine use during CT. Here, we discuss the prothrombotic effects of various antitumor agents aimed at gaining deeper understanding of the underlying mechanisms that may allow to develop new strategies for prevention and treatment of such formidable complications.
Authors
- G. Gerotziafas
- N. R. Gashimova (ORCID: https://orcid.org/0000-0003-0764-4477)
- К. N. Grigoreva (ORCID: https://orcid.org/0000-0002-7756-8935)
- Д. В. Блинов (ORCID: https://orcid.org/0000-0002-3367-9844)
- N. А. Makatsariya (ORCID: https://orcid.org/0000-0002-2541-3843)
- В. Н. Галкин (ORCID: https://orcid.org/0000-0002-6619-6179)
- Siman Morkos (ORCID: https://orcid.org/0009-0001-2378-2477)
- Наталія Валеріївна Шульга
- Е. V. Slukhanchuk (ORCID: https://orcid.org/0000-0001-7441-2778)
- J. Kh. Khizroeva (ORCID: https://orcid.org/0000-0002-0725-9686)
- В. О. Бицадзе (ORCID: https://orcid.org/0000-0001-8404-1042)
- Jean‐Christophe Gris (ORCID: https://orcid.org/0000-0002-9899-9910)
- Ismaı̈l Elalamy (ORCID: https://orcid.org/0000-0002-9576-1368)
- А. Г. Солопова (ORCID: https://orcid.org/0000-0002-7456-2386)
- А. D. Makatsariya (ORCID: https://orcid.org/0000-0001-7415-4633)
- A. Yu. Shatilina
- E. M. Lyadnova
- L. T. Toguzaeva
Institutions
- Sechenov University (RU)
- Lomonosov Moscow State University (RU)
- Université de Montpellier (FR)
- Sorbonne Université (FR)
- National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation (RU)
- City Clinical Hospital (RU)
- Institute of Social and Preventive Medicine (CH)
- Moscow State University (TJ)
- Hôpital Tenon (FR)
Publication Details
- Journal
- Obstetrics Gynecology and Reproduction
- Published
- 2025-01-10
- DOI
- https://doi.org/10.17749/2313-7347/ob.gyn.rep.2024.579
- Citations
- 1
- Primary Topic
- Venous Thromboembolism Diagnosis and Management
- Type
- article
- Field-Weighted Citation Impact
- 1.87