Features of clinical symptoms, endocrine status and echographic changes are at pathology of mammary gland

The objective: study of features of endocrine status, echographic changes and clinical symptoms fibrocystic disease.Materials and methods. An inspection was conducted 100 patients with a diagnosis fibrocystic disease. The criteria of including for it were: age 20-49 years; presence of clinical, ultrasonic, morphological signs fibrocystic disease; index of mass of body of not more than 29,9 kg/m2. The criteria of exception from research served as: suspecting or confirmation of malignant process is of mammary gland, pregnancy, puerperium, lactation, use during the last 6 months hormonal facilities. The group of comparison was made by 50 women. The criteria of including for it were: age 20–49 years, absence of clinical symptoms of disease of mammary gland, absence of hyperplastic processes in other organs of the reproductive system, regular menstrual cycle. Results. Nosotropic value clinical-and-anamnestic factors in development fibrocystic disease it is determined by postnatal character morpho-functional to development of mammary gland, which is synchronized with the periods of becoming of ovulatory and hormonal functions of ovaries by realization of reproductive function of woman. Found out by us factors can influence on development of terminal lobular-ductal unit of organ, biological properties of its tissue, create the backgrounds of development of dysplastic process. Conclusions. The got results testify to the nosotropic value of clinical-and-anamnestic factors in development fibrocystic disease, which is determined by postnatal character morpho-functional to development of mammary gland, which is synchronized with the periods of becoming of ovulatory and hormonal functions of ovaries by realization of reproductive function of woman. Rotined dependence of intensity of pain syndrome on age of patients, indexes of hormonal function of ovaries, development of parenchima and degree of it cyclic transformation. Thus, the plural regressive analyze allowed to set that basic factors which influence on intensity of mastalgia is a thickness of parenchyma (F=58,17; р<0,001) and level in blood of estradiol (F=154,92; р<0,001) in the second phase of menstrual cycle. The got results it must draw on at development of complex of diagnostic and treatment-and-prophylactic measures.Keywords: combined pathology of mammary gland, clinical symptoms, endocrine status, echographic changes.