D-dimer, Fibrinogen and their association with IL-17 as a Risk factor of Cardiovascular events in Psoriasis Patients

Abstract: Background: Psoriasis is an inflammation disease linked with the risk of venous thromboembolism (VTE), metabolic syndrome, and increased atherosclerotic arterial disease risk, especially in severe cases, The factors that are thought to contribute to VTE are hypercoagulability, endothelial injury and venous stasis. Objectives: The research attempts for searching into sensitivity as well as specificity of D-dimer and Fibrinogen and their relationships with IL-17 represents a heart disease hazards with moderately severe psoriasis. Materials and Methods: This case-control study enrolled 50 male patients with psoriasis range aged 15 to 60 years, were matched by age and sex with 50 healthy controls, at Hospitals of the Morgan Teaching and Imam Sadiq in Babylon province, Iraq, between July to October of 2023. The psoriatic scores and levels of D-dimer, Fibrinogen and IL-17 in sera and psoriatic CVD complications were measured. Correlations and Methods of logistical regressing have been applied for these markers for predict within venous thrombotic events. Results: Psoriasis patients had significantly higher levels of D-dimer, Fibrinogen as well as ILـ17 levels (p<0,01) more than controllingـgroup. A positive matrix correlation of these markers with PASI. Logistic regression analysis of psoriasis severity predicts with a higher significant OR of 2.636 (95% CI: 1.317 - 5.277) associated with CVD events compared to those without CVD. In addition to ROC analysis indicates a discriminatory capacity predicted for CVD events in psoriasis patients that D-dimer of AUC (95% CI): 0.901(0.818-0.984), and Fibrinogen was 0.888 (0.797-0.978), while, IL-17 was AUC (95% CI): 0.892 (0.799-0.985). Conclusion: D-dimer and Fibrinogen along with higher IL-17 levels has been identified as a predict factors for greater danger of cardiovascular illnesses in individuals having moderately to severely severe psoriasis.