Genome-wide association study of urinary cadmium levels in current smokers from the multiethnic cohort study
Our GWAS of urinary Cd levels in a diverse population of people who smoke, revealed suggestive associations with variants in SCARA5, NIPBL, SPINK4, SLC9A7, and 5p13.3. These findings underscore the potential role of genetic factors in understanding and mitigating the health risks associated with internal dose of carcinogens, particularly in the context of tobacco-related carcinogens.
Authors
- Lynne Ross Wilkens (ORCID: https://orcid.org/0000-0001-8408-4536)
- Sharon E. Murphy (ORCID: https://orcid.org/0000-0001-5391-8104)
- Daniel O. Stram (ORCID: https://orcid.org/0000-0001-7099-9022)
- Irina Stepanov (ORCID: https://orcid.org/0000-0001-5140-8944)
- Loı̈c Le Marchand (ORCID: https://orcid.org/0000-0001-5013-980X)
- S Lani Park
- Shannon M. Sullivan (ORCID: https://orcid.org/0000-0003-1430-8455)
- Christopher A. Haiman
Institutions
- University of Southern California (US)
- University of Hawaiʻi at Mānoa (US)
- University of Minnesota (US)
- University of Hawaii System (US)
- Cancer Center of Hawaii (US)
- Minnesota Department of Health (US)
- University of Hawaii Cancer Center
Publication Details
- Journal
- Human Molecular Genetics
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1093/hmg/ddae202
- Citations
- 1
- Primary Topic
- Heavy Metal Exposure and Toxicity
- Type
- article
- Field-Weighted Citation Impact
- 0.31
Funders
- University of Minnesota
- University of Hawai'i
- Centers for Disease Control and Prevention
- National Institute for Occupational Safety and Health