Subthalamic and nigral stimulation for freezing of gait in Parkinson's disease: Randomized pilot trial
Our study did not prove a statistically significant improvement in NFOG-Q with STN-SNr stimulation; however, one-third of patients experienced a clinically meaningful FoG improvement, and the majority preferred to maintain STN-SNr stimulation. STN-SNr stimulation was both safe and effective in addressing motor complications and improving sleep quality, highlighting the importance of further exploration into the effects of combined STN-SNr stimulation.
Authors
- Alberto Romagnolo (ORCID: https://orcid.org/0000-0002-1312-1843)
- Raquel Barbosa (ORCID: https://orcid.org/0000-0002-3138-2975)
- Maurizio Zibetti (ORCID: https://orcid.org/0000-0002-2939-343X)
- Silvia Gallo (ORCID: https://orcid.org/0000-0001-7223-2060)
- Amaury De Barros (ORCID: https://orcid.org/0000-0001-9724-8616)
- Domiziana Rinaldi (ORCID: https://orcid.org/0000-0002-8011-087X)
- Claire Thalamas (ORCID: https://orcid.org/0000-0003-1893-519X)
- Leonardo Lopiano (ORCID: https://orcid.org/0000-0001-9098-387X)
- Olivier Rascol (ORCID: https://orcid.org/0000-0002-1410-6397)
- Vanessa Rousseau (ORCID: https://orcid.org/0000-0001-7518-7891)
- Mario Giorgio Rizzone (ORCID: https://orcid.org/0000-0003-3844-3299)
- C. Campisi (ORCID: https://orcid.org/0000-0002-3565-8764)
- Gabriele Imbalzano (ORCID: https://orcid.org/0000-0002-4842-529X)
- Estelle Harroch
- Fabienne Ory‐Magne (ORCID: https://orcid.org/0000-0001-6179-4500)
- Margherita Fabbri (ORCID: https://orcid.org/0000-0001-7250-592X)
- Jean Luc Houeto (ORCID: https://orcid.org/0000-0002-6029-8289)
- Carlo Alberto Artusi (ORCID: https://orcid.org/0000-0001-8579-3772)
- Claudia Ledda (ORCID: https://orcid.org/0000-0003-0839-932X)
- Christine Brefel‐Courbon (ORCID: https://orcid.org/0009-0002-7262-2338)
Institutions
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- Inserm (FR)
- Université Fédérale de Toulouse Midi-Pyrénées (FR)
- Centre Hospitalier Universitaire de Toulouse (FR)
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- Observatoire Midi-Pyrénées (FR)
- Institut d’Epidémiologie Neurologique et de Neurologie Tropicale (FR)
- French Clinical Research Infrastructure Network (FR)
- University of Turin (IT)
- Université de Limoges (FR)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Journal of Parkinson s Disease
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1177/1877718x241292315
- Citations
- 3
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.11
Funders
- Université de Toulouse