Family foci of HDV infection in the Republic of Sakha (Yakutia)

This study is devoted to the analysis of the epidemiological situation of chronic hepatitis D in Yakutia, as a region where chronic viral hepatitis is widespread. Aim: To characterize family foci of chronic hepatitis D in the Republic of Sakha (Yakutia). Materials and methods : The study is based on data from the registry “Chronic viral hepatitis in the Republic of Sakha (Yakutia)” and official statistics of the Territorial Administration of Rospotrebnadzor in the Republic of Sakha (Yakutia) for 2013­2023. There was conducted an analysis of case histories of patients with chronic hepatitis D, including those from family foci of HDV infection (n = 13). Statistical data processing was carried out using the IBM SPSS Statistics 26.0 program. Results: The article presents data on the number of registered cases of chronic forms of viral hepatitis B and D in Yakutia, analyzed family foci of HDV infection, highlights of the features of infection and the dynamics of disease development in family groups associated with infection of spouses and perinatal transmission. Conclusion : The work reflects the importance of natural routes of transmission of HDV infection and emphasizes the relevance of perinatal prevention of hepatitis B, including the use of vaccination and specific HBV immunoglobulin for family members with replicative form of hepatitis B and D. This study has practical significance for the development of programs for the prevention and early detection of HDV infection.