Aberrant acetylation caused by a <i>CDYL</i> splicing mutation contributes to thin mid‐piece related asthenoteratozoospermia and male infertility
We demonstrated that a homozygous CDYL splicing mutation specifically induces a decrease in microtubule acetylation, resulting in thin mid-piece related asthenoteratozoospermia, providing a novel marker for genetic counseling and diagnosis of male infertility.
Authors
- Yang Gao (ORCID: https://orcid.org/0000-0002-9068-9993)
- Bing Han (ORCID: https://orcid.org/0000-0002-3315-8950)
- Mingrong Lv (ORCID: https://orcid.org/0000-0001-8817-7350)
- Zhaolian Wei
- Bing Song (ORCID: https://orcid.org/0000-0002-7182-0175)
- Ping Zhou (ORCID: https://orcid.org/0000-0002-0643-8527)
- Xiaojin He (ORCID: https://orcid.org/0000-0001-5919-8478)
- Guanxiong Wang (ORCID: https://orcid.org/0000-0002-6816-7988)
- Huan Wu (ORCID: https://orcid.org/0000-0002-0009-3839)
- Cao Yun-xia (ORCID: https://orcid.org/0000-0003-3150-8459)
- Yuping Xu (ORCID: https://orcid.org/0000-0002-2034-1086)
- Dongdong Tang (ORCID: https://orcid.org/0000-0002-9966-3642)
- Liting Liu (ORCID: https://orcid.org/0000-0002-6247-9147)
- Qunshan Shen (ORCID: https://orcid.org/0000-0002-3237-0829)
- Wen Zhu (ORCID: https://orcid.org/0009-0008-5700-3284)
- Fan Yang (ORCID: https://orcid.org/0000-0002-9693-4099)
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Shanghai Jiao Tong University (CN)
- Anhui Medical University (CN)
- Shanghai Mental Health Center (CN)
- V.I.Shumakov Federal Research Center of Transplantology and Artificial Organs (RU)
- Anhui Provincial Hospital (CN)
- Shanghai First People's Hospital (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Andrology
- Published
- 2025-01-16
- DOI
- https://doi.org/10.1111/andr.13825
- Citations
- 1
- Primary Topic
- Sperm and Testicular Function
- Type
- article
- Field-Weighted Citation Impact
- 1.70
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China