Aberrant acetylation caused by a <i>CDYL</i> splicing mutation contributes to thin mid‐piece related asthenoteratozoospermia and male infertility

We demonstrated that a homozygous CDYL splicing mutation specifically induces a decrease in microtubule acetylation, resulting in thin mid-piece related asthenoteratozoospermia, providing a novel marker for genetic counseling and diagnosis of male infertility.

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Publication Details

Journal
Andrology
Published
2025-01-16
DOI
https://doi.org/10.1111/andr.13825
Citations
1
Primary Topic
Sperm and Testicular Function
Type
article
Field-Weighted Citation Impact
1.70

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article

Aberrant acetylation caused by a CDYL splicing mutation contributes to thin mid‐piece related asthenoteratozoospermia and male infertility

Yang Gao, Bing Han, Mingrong Lv, Zhaolian Wei et al.
1 citations
Andrology
Sperm and Testicular Function
1.70
article

Aberrant acetylation caused by a CDYL splicing mutation contributes to thin mid‐piece related asthenoteratozoospermia and male infertility

Yang Gao, Bing Han, Mingrong Lv, Zhaolian Wei, Bing Song, Ping Zhou, Xiaojin He, Guanxiong Wang, Huan Wu, Cao Yun-xia, Yuping Xu, Dongdong Tang, Liting Liu, Qunshan Shen, Wen Zhu, Fan Yang
article en
1 citations

Abstract

We demonstrated that a homozygous CDYL splicing mutation specifically induces a decrease in microtubule acetylation, resulting in thin mid-piece related asthenoteratozoospermia, providing a novel marker for genetic counseling and diagnosis of male infertility.

AndrologyVol. 13(8)
Ministry of Education of the People's Republic of China (CN), Shanghai Jiao Tong University (CN), Anhui Medical University (CN), Shanghai Mental Health Center (CN), V.I.Shumakov Federal Research Center of Transplantology and Artificial Organs (RU), Anhui Provincial Hospital (CN), Shanghai First People's Hospital (CN), First Affiliated Hospital of Anhui Medical University (CN)
National Natural Science Foundation of China, National Key Research and Development Program of China
Openalex Percentile: Top 20%
Sperm and Testicular Function
1.70
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