Possibilities of rational application of bacteriophages in the therapy of infections caused by polyresistant strains of Klebsiella pneumoniae

The issue of combating antimicrobial resistance has been relevant for several decades, since the arsenal of effective antibiotics used in infectious diseases is significantly reduced, and the development of new antibacterial drugs is significantly difficult and expensive. At the same time, the possibility of widespread use of bacteriophages in hospital settings is being discussed. Goal. Evaluation of the sensitivity to bacteriophages of hospital strains of K.pneumoniae isolated from patients in the departments of surgery and intensive care and intensive care of the Structure Clinical Infectious Disease Hospital named after S.P.Botkin. Materials and methods . The activity of bacteriophage preparations “Sextafag” (series p158, p220, p242), “Klebsiell polyvalent bacteriophage” (series y04, y07, y10, y16), “Polyvalent Pyobacteriophage purified” (series y10, y291022) (Manufacturer: NPO Microgen JSC, Moscow) was determined by preparing suspensions of microorganisms, their sowing on nutrient media with subsequent application of bacteriophages, taking into account and interpreting the results. Results . The majority of polyresistant K.pneumoniae strains showed sensitivity to the presented bacteriophage preparations, which allows them to be considered as additional antibacterial agents for the treatment of these groups of patients. Conclusion . The presented results of the study showed that hospital polyand pan­resistant strains of K.pneumoniae are sensitive to preparations of monoand polyvalent bacteriophages, which can be considered as a potential alternative in conditions of antibiotic resistance. The study did not reveal a link between the antibiotic resistance profile of the culture and sensitivity to bacteriophages.