Evaluation of de novo donor specific antibodies after kidney transplantation in the era of donor-derived cell-free DNA
These findings highlight the correlation between cumulative dnDSA MFI and dd-cfDNA levels, particularly in HLA-DQ-directed dnDSA, and suggest graft injury is dynamic in dnDSA-positive patients. Integrated monitoring of dnDSA and dd-cfDNA offers a promising non-invasive approach for assessing graft injury and alloimmunity, potentially enhancing post-transplant care.
Authors
- Thomas Schachtner (ORCID: https://orcid.org/0000-0001-5549-4798)
- Yuan Tian (ORCID: https://orcid.org/0000-0001-5732-7045)
- Lukas Frischknecht (ORCID: https://orcid.org/0000-0001-5666-5747)
- Jakob Nilsson (ORCID: https://orcid.org/0000-0001-5091-8133)
- Anna Mallone (ORCID: https://orcid.org/0000-0002-7949-9718)
- Fabian Rössler (ORCID: https://orcid.org/0000-0002-2968-347X)
Institutions
- University Hospital of Zurich (CH)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-01-16
- DOI
- https://doi.org/10.3389/fimmu.2024.1530065
- Citations
- 7
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 13.90
Funders
- European Commission
- Innosuisse - Schweizerische Agentur für Innovationsförderung