Optimization of Felbinac Nanoemulgel - Formulation and Evaluation Employing Advanced Statistical Mixture Design Approach

Nanoemulgel represents an advanced topical drug delivery system integrating Nanoemulsions and Hydrogels. By blending the stability of nanoscale emulsions with the prolonged release of hydrogels, it improves drug penetration and bioavailability. This advancement shows potential for effective and precise pharmaceutical delivery, especially in dermatological contexts. Optimal Mixture design, a statistical method within the experimental design is employed to fine-tune formulations involving multiple components. In the context of Nanoemulsion development, this approach aids in pinpointing the ideal composition that aligns with specific properties by systematically exploring various component combinations facilitating the optimization of Nanoemulgel formulations.The investigation included the assessment of droplet size, zeta potential, polydispersity index (PDI) and stability studies. Additionally, morphological characterization through SEM revealed encouraging outcomes.The Felbinac Nanoemulgel showed enhanced drug release up to 93.63 % and a highly significant difference in therapeutic effectiveness (89.43 %) compared to standard formulation (72.45 %) by anti-inflammatory animal model. Data analysis was performed using two-way ANOVA followed by the Bonferroni post hoc test, confirming the efficacy of the Nanoemulgel in reducing inflammation.