Population pharmacokinetic model of tranexamic acid in patients who undergo cardiac surgery with cardiopulmonary bypass
Patients who undergo cardiac surgery with CPB may require an adjusted dose of TXA tailored to CPB due to lower CL<sub>1</sub> and increased V<sub>1</sub>. Our TXA population pharmacokinetic model may be useful for developing individualized dosing designs for TXA in patients who undergo cardiac surgery with CPB.
Authors
- Hiroyuki Mizoguchi (ORCID: https://orcid.org/0000-0001-6993-4184)
- Masato Mutsuga (ORCID: https://orcid.org/0000-0001-9740-2142)
- Kimitoshi Nishiwaki (ORCID: https://orcid.org/0000-0002-1219-9294)
- Shigeki Yamada (ORCID: https://orcid.org/0000-0001-7158-5569)
- Takahiro Tamura (ORCID: https://orcid.org/0000-0001-6916-9988)
- Takayuki Inagaki (ORCID: https://orcid.org/0009-0000-9147-556X)
- Kiyofumi Yamada (ORCID: https://orcid.org/0000-0002-5280-5180)
- Yasuhiro Miyagawa
- T. NAKAI
Institutions
- Nagoya University Hospital (JP)
- Fujita Health University Hospital (JP)
- Nagoya University (JP)
- Meijo University (JP)
Publication Details
- Journal
- European Journal of Clinical Pharmacology
- Published
- 2025-01-16
- DOI
- https://doi.org/10.1007/s00228-025-03802-0
- Citations
- 1
- Primary Topic
- Blood transfusion and management
- Type
- article
- Field-Weighted Citation Impact
- 0.77
Funders
- Nagoya University