The impact of CD3ζ ITAM multiplicity and sequence on CAR T-cell survival and function

Since, weaker signaling ζCCC CARs favored less cell death, exhaustion and differentiation, they might be better candidates for improving long term survival and persistence of CAR T cells in patients.

Authors

Institutions

Publication Details

Journal
Frontiers in Immunology
Published
2025-01-16
DOI
https://doi.org/10.3389/fimmu.2024.1509980
Citations
4
Primary Topic
CAR-T cell therapy research
Type
article
Field-Weighted Citation Impact
4.18

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

The impact of CD3ζ ITAM multiplicity and sequence on CAR T-cell survival and function

Hilda Echelibe, Shubhabrata Majumdar, Maria Bettini, Matthew L. Bettini
4 citations
Frontiers in Immunology
CAR-T cell therapy research
4.18
article

The impact of CD3ζ ITAM multiplicity and sequence on CAR T-cell survival and function

Hilda Echelibe, Shubhabrata Majumdar, Maria Bettini, Matthew L. Bettini
article en
4 citations

Abstract

Since, weaker signaling ζCCC CARs favored less cell death, exhaustion and differentiation, they might be better candidates for improving long term survival and persistence of CAR T cells in patients.

Frontiers in ImmunologyVol. 15
Baylor College of Medicine (US), University of Utah (US)
National Institutes of Health, National Cancer Institute
Openalex Percentile: Top 7%
CAR-T cell therapy research
4.18
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.