Exploring the composition of placental microbiome and its potential origin in preterm birth
Our analysis revealed distinct profiles in the oral microbiome of PTB subjects compared to those who delivered at term. Specifically, we observed an increased abundance of Treponema maltophilum, Bacteroides sp, Mollicutes, Prevotella buccae, Leptotrichia, Prevotella_sp_Alloprevotella, in the PTB group. Importantly, Treponema maltophilum species showed higher abundance in the PTB group during the second trimester, suggesting its potential use as biomarkers. When we assessed the placenta microbiome composition, we found that Firmicutes, Bacteroidetes, Actinobacteria, and Proteobacteria were the most dominant phyla. Interestingly, microorganisms such as Ureaplasma urealyticum were more abundant in PTB placenta samples. Our findings suggest that the placenta microbiome could originate from the oral or vaginal cavities, with a notable increase in the crosstalk between the vaginal and placental sites in cases of PTB. Specifically, our data revealed that in PTB cases, the placental microbiome exhibited a closer resemblance to the vaginal microbiome, whereas in term pregnancies, the placental microbiome was similar to the oral microbiome.
Authors
- Tobias Brummaier (ORCID: https://orcid.org/0000-0002-9739-2084)
- Annalisa Terranegra (ORCID: https://orcid.org/0000-0001-9274-5373)
- Selvasankar Murugesan (ORCID: https://orcid.org/0000-0001-8386-6536)
- Mohamed Nadhir Djekidel (ORCID: https://orcid.org/0000-0001-5361-1858)
- Damien Chaussabel (ORCID: https://orcid.org/0000-0002-6131-7242)
- Souhaila Al Khodor (ORCID: https://orcid.org/0000-0003-4858-7130)
- Basirudeen Syed Ahamed Kabeer (ORCID: https://orcid.org/0000-0002-7287-1636)
- Duaa Ahmed Elhag (ORCID: https://orcid.org/0000-0001-7086-6019)
- Tomoshige Kino (ORCID: https://orcid.org/0000-0003-0220-9396)
- Marwa Saadaoui
- Manoj Kumar (ORCID: https://orcid.org/0000-0003-0671-4357)
- Parul Singh (ORCID: https://orcid.org/0000-0002-0438-3024)
- Alexandra K. Marr (ORCID: https://orcid.org/0000-0002-1478-9140)
- Rose McGready (ORCID: https://orcid.org/0000-0003-1621-3257)
- François Henry Nosten (ORCID: https://orcid.org/0000-0002-7951-0745)
Institutions
- Mahidol University (TH)
- University of Oxford (GB)
- Shoklo Malaria Research Unit (TH)
- Jackson Laboratory (US)
- Mahidol Oxford Tropical Medicine Research Unit (TH)
- Saveetha University (IN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-01-16
- DOI
- https://doi.org/10.3389/fcimb.2024.1486409
- Citations
- 8
- Primary Topic
- Preterm Birth and Chorioamnionitis
- Type
- article
- Field-Weighted Citation Impact
- 10.83