Exploiting somatic oncogenic driver alterations in a patient with Li-Fraumeni syndrome– paving the path towards precision medicine: a case report
In the era of accessible and comprehensive genetic and phenotypic tumor profiling, this case study of a patient with Li-Fraumeni syndrome underscores the success of precision oncology in harnessing additional somatic oncogenic driver alterations. Furthermore, it emphasizes the indispensable role of an interdisciplinary molecular tumor board, enhancing the awareness of molecular profiling and targeted therapies in patients with rare cancer susceptibility disorders.
Authors
- Ralf Marienfeld (ORCID: https://orcid.org/0000-0002-1309-1429)
- Uwe Gerstenmaier
- Brigitte Rack (ORCID: https://orcid.org/0000-0002-7539-4839)
- Stephan Stilgenbauer (ORCID: https://orcid.org/0000-0002-6830-9296)
- Sonja Dahlum
- Reiner Siebert (ORCID: https://orcid.org/0000-0001-7433-3703)
- Wolfgang Thaiss (ORCID: https://orcid.org/0000-0002-0796-780X)
- Carolin Seeling
- Vera Jan
- Ambros J. Beer (ORCID: https://orcid.org/0000-0001-9042-7806)
- Nadine Therese Gaisa (ORCID: https://orcid.org/0000-0002-4762-3964)
- Verena I. Gaidzik
- Hartmut Döhner (ORCID: https://orcid.org/0000-0003-2116-5536)
- Thomas F.E. Barth (ORCID: https://orcid.org/0000-0002-3379-6311)
- T Seufferlein
- Wolfgang Janni
- Regine Mayer‐Steinacker
Institutions
- Universität Ulm (DE)
- University Hospital Ulm (DE)
Publication Details
- Journal
- Journal of Cancer Research and Clinical Oncology
- Published
- 2025-01-16
- DOI
- https://doi.org/10.1007/s00432-024-06077-7
- Primary Topic
- Cancer-related Molecular Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00