Effectiveness of an ECM-derived biomaterial in promoting post-operative tissue regeneration after tooth extraction

Relevance. Tooth extractions are one of the most common surgical procedures in dentistry. Tissue regeneration at the extraction site plays a vital role in restoring the affected area. Various methods are available to accelerate and improve the quality of tissue regeneration in dental practice. Extracellular matrix (ECM)-derived biomaterials provide a wide range of therapeutic and regenerative benefits due to their unique biological properties. This study aimed to evaluate the effectiveness of an ECM-derived biomaterial in promoting post-operative tissue regeneration after tooth extraction. Materials and methods. The study included two groups of patients: an experimental group (N = 46) and a control group (N = 46), all of whom underwent tooth extractions. The groups were compared based on two key parameters: the time required for complete wound surface healing and the time to achieve complete radiographic wound healing. Statistical analysis was conducted using the non-parametric Mann-Whitney U test for independent samples. The incidence of complications between the groups was analyzed using Fisher's exact test. Results. The analysis of wound surface healing times between the groups revealed statistically significant differences (p < 0.05). Post-operative tissue repair occurred at a significantly faster rate in the group treated with the extracellular matrix (ECM)-derived biomaterial compared to the control group. Conclusion. Tissue regeneration at the surgical site after tooth extraction is a manageable process. Advances in modern biomaterials have facilitated accelerated tissue healing and functional recovery, leading to improved quality of life for patients.