Determination of Antimicrobial Potency of some Polar Solvent Extracts of Polypore Mushrooms

Numerous antimicrobial-resistant microorganisms have been discovered in the present scenario, leading to drug development challenges. The concerning of drug development has needed to search for new antimicrobial agents. The mushrooms are a rich source of potential antimicrobial agents. In this study, the antimicrobial potential of the polar solvent (hot water, methanol, and ethanol) extracts of four wild polypore mushrooms (Daedaleopsis confragosa (from two different sites), Schizophyllum commune and Laetiporus sulphurous) was estimated. The present study's in vitro antimicrobial activity was investigated by the Minimum inhibitory concentration (MIC) against pathogen and non-pathogenic microbes, including bacterium (Bacillus cereus McR-3, Bacillus subtilis BAB 2437 and Klebsiella oxytoca ATCC 13182) and fungus (Aspergillus ustus MTCC 2200 and Cunninghamella elegans MTCC 552) respectively. The result revealed that the isolated extract showed a selective antimicrobial capacity. The growth inhibitory analysis indicated that all the polar solvent extracts showed antimicrobial properties. The methanolic extracts revealed maximum antibacterial, and similarly, water and ethanol extracts gave moderate antifungal activities. The result suggested that polypore mushroom has the best natural resources, including good antimicrobial activity potency and nutritional constituents for human health. Therefore, it recommends developing a remedy for human health instead of synthesized drugs.