Role of IL-1β, IL-6, IL-10, IgG, IgA, PMN, Macrophage, and Cortisol on Psychological Stress Mechanisms in Periodontal Disorders

Periodontitis disorders can result in disease Periodontitis is a chronic, destructive, and irreversible inflammatory disease. Stress is a direct cause of periodontal problems which is connected through neuro-immunoendocrinological mechanisms. It can be caused by many things, the discrepancy between expectations and reality, physical pressure, psychological pressure, and others. Stress can cause changes in interleukin expression, hormone expression, protein expression, and the number of PMNs and macrophages. This study used Wistar rats with two treatment groups and one control group with the following conditions: male type, weight 300grams, age 5 months. Each treatment group was exhausted (treadmill) for 15 minutes and rested for 45 minutes and the treatment group was afraid (cats as predators of mice). Statistically, the role of IL-1β, IL-6, IL-10, Ig G, Ig A, PMN, Macrophage, and Cortisol has an effect on periodontitis Overall examination showed that the description of the effect of psychological stress on periodontal disorders in Wistar rats. The highest IL-1β expression on the first day of running (L1) and the predator treatment (P1) on the first day also showed a high value, the role of IL-1β as the main biomarker of the effects of chronic stress. is by increasing IL-1β converting these inflammatory signals into nerve signals and with the endocrine system (melatonin and cortisol) to compensate. In conclusion, the Widening of the periodontal tissue under stress conditions as a marker of periodontal disorders in Wistar rats shows the main role of all variables in the mechanism of psychological stress in periodontal disorders.