Development and Comparative Analysis of Probiotic-Enhanced Aceclofenac Tablets for Colon-Specific Delivery in Pharmaceuticals

In this research, we developed a novel approach to formulate colon-specific matrix tablets containing Aceclofenac. Employing the wet granulation method, we integrated guar gum as the polymeric matrix and harnessed the potential of probiotics as targeting aids. Our investigation revealed a remarkable capability of this methodology to achieve colonic release of the drug, even in the absence of colonic microflora, while ensuring sustained drug release from the formulations. The outcomes underscore the promise of the probiotic-assisted procedure in yielding matrix tablets with exceptional release behavior, actively targeting drug delivery to the colon. Consequently, this innovative delivery system presents a unique and promising strategy for the treatment of stomach ulcers and other gastrointestinal ailments. This research represents a significant advancement in pharmaceutical science, offering a distinctive approach to address targeted drug delivery challenges in gastrointestinal therapeutics.