Oncoproteins E6/E7 of the human papillomavirus types 16 & 18 synergize in modulating oncogenes and tumor suppressor proteins in colorectal cancer
Our data imply that HPV coinfections leads to the sustenance of a pro-oncogenic environment in CRC. HPV modulates different oncogenes/tumor suppressor proteins in CRC of varying mutational backgrounds, thus highlighting the importance of personalized therapies for such diseases with mutational heterogeneity.
Authors
- Shahd M. Younis (ORCID: https://orcid.org/0009-0005-3742-3554)
- Lubna Therachiyil
- Ala‐Eddin Al Moustafa (ORCID: https://orcid.org/0000-0003-4452-3439)
- Queenie Fernandes (ORCID: https://orcid.org/0009-0008-3253-3529)
- Said Dermime (ORCID: https://orcid.org/0000-0002-5526-7496)
Institutions
- National Center for Cancer Care and Research (QA)
- Hamad Medical Corporation (QA)
- McGill University (CA)
- Qatar University (QA)
Publication Details
- Journal
- Expert Review of Proteomics
- Published
- 2025-01-16
- DOI
- https://doi.org/10.1080/14789450.2025.2455104
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00