The impact of body mass index on mortality according to age in hemodialysis patients: an analysis of the Korean Renal Data System
The impact of age on the relationship between body mass index (BMI) and all-cause mortality in hemodialysis (HD) patients is not clearly understood. Using data from the Korean Renal Data System (2001-2022), we analyzed 66,129 HD patients, stratified into young (<65 years, n = 24,589), younger-old (65-74 years, n = 17,732), and older-old (≥75 years, n = 23,808) groups. Patients were categorized into BMI quartiles, and survival outcomes were evaluated using Kaplan-Meier curves and event time ratios for the relative change in the survival time. During the follow-up period, 14,360 of the patients (21.7%) died, with a median follow-up of 3.4 years. Kaplan-Meier curves revealed poorer outcomes in lower BMI quartiles across all age groups. The lowest BMI quartile was significantly associated with a shorter survival time compared to the highest BMI quartile, with a 15% reduction in the young group (p = 0.001) and a 12% reduction in the older-old group (p = 0.002). Predicted survival time increases with rising BMI in the young group, but the rate of increase slows in the younger-old group and plateaus in the older-old group after a BMI of 25 kg/m2. Lower BMI correlates with higher mortality, particularly in younger HD patients.
Authors
- Yu Ah Hong (ORCID: https://orcid.org/0000-0001-7856-4955)
- Chang-Yun Yoon (ORCID: https://orcid.org/0000-0001-8545-9344)
- Kyeong Min Kim
- Seon-Ho Ahn (ORCID: https://orcid.org/0000-0002-3482-1056)
- Young-Kyoung Cho
- Hye Eun Yoon (ORCID: https://orcid.org/0000-0002-6347-7282)
- Hoseok Koo (ORCID: https://orcid.org/0000-0001-7856-8083)
- Seon A Jeong (ORCID: https://orcid.org/0009-0009-1615-5983)
- Hajeong Lee (ORCID: https://orcid.org/0000-0002-1873-1587)
- Sun Ryoung Choi (ORCID: https://orcid.org/0000-0002-9668-3349)
- Tae Hyun Ban (ORCID: https://orcid.org/0000-0002-2884-4948)
- Hyunglae Kim (ORCID: https://orcid.org/0000-0002-4792-0328)
- Tae Hee Kim (ORCID: https://orcid.org/0000-0002-3001-234X)
- Ji Hyun Kim (ORCID: https://orcid.org/0000-0001-8477-0157)
- Yong Kyun Kim (ORCID: https://orcid.org/0000-0002-1871-3549)
- Su Hyun Kim (ORCID: https://orcid.org/0000-0003-3382-528X)
- Kiwon Kim (ORCID: https://orcid.org/0000-0002-2885-0053)
- Seun Deuk Hwang (ORCID: https://orcid.org/0000-0003-0074-6972)
Institutions
- Inje University (KR)
- Inha University (KR)
- Eulji University (KR)
- Sahmyook Medical Center (KR)
- Seoul National University Hospital (KR)
- Seoul National University Bundang Hospital (KR)
- The Catholic University of Korea St. Vincent's Hospital (KR)
- The Catholic University of Korea Incheon St. Mary's Hospital (KR)
- The Catholic University of Korea Daejeon St. Mary's Hospital (KR)
- The Korean Society of Nephrology (KR)
- Chung-Ang University (KR)
- Wonkwang University (KR)
- Catholic University of Korea (KR)
Publication Details
- Journal
- Kidney Research and Clinical Practice
- Published
- 2025-01-16
- DOI
- https://doi.org/10.23876/j.krcp.24.160
- Citations
- 4
- Primary Topic
- Dialysis and Renal Disease Management
- Type
- article
- Field-Weighted Citation Impact
- 5.72
Funders
- Korean Society of Nephrology