Impact of Azoospermia on Quality of Life: Insights from a Multi-Centric Cross-Sectional Study

Purpose: This cross-sectional study aims to evaluate the Quality of Life (QoL) among infertile couples with azoospermia attending infertility clinics and to explore its associations with various socio-demographic, medical, and personal characteristics.The primary research question focuses on identifying the factors influencing QoL in this population, utilizing both the Fertility Quality of Life (Ferti QoL) questionnaire and WHOQOL-BREF for assessment.Methods: The study was conducted across multiple infertility clinics to ensure a diverse demographic and socio-economic representation.Participants included infertile couples undergoing in-vitro fertilization (IVF) treatment, with male infertility attributed to azoospermia.Data collection involved semi-structured questionnaires covering socio-demographic information, medical history, and QoL assessments.Statistical analyses comprised descriptive statistics, chi-square tests, t-tests, and multiple linear regression analyses to explore associations between the characteristics and QoL.Results: Preliminary findings from the study indicate a range of factors influencing the Quality of Life (QoL) among infertile male partners(n=719) with azoospermia.Age was found to negatively impact mind/body scores, with older participants reporting lower QoL in this domain (=-2.00,p=0.164).Male participants exhibited lower levels of social interaction, which was attributed to the fear of being ostracized.Rural residents reported significantly lower QoL compared to their urban counterparts, highlighting the impact of residential status on overall well-being.Higher levels of education were associated with poorer social well-being scores