The Multifaceted Role of lncRNA GAS5: A Pan-Cancer Analysis of Its Diagnostic, Prognostic, and Therapeutic Potential

This comprehensive analysis across various cancers offers a significant foundation for GAS5 as a potential diagnostic and prognostic biomarker, especially prominent in LIHC, with additional relevance in KIRC. Identification of tissue-specific regulatory mechanisms and correlations with immune cells opens new perspectives into the context-dependent functionality of GAS5. These findings highlight the potential of GAS5 for developing targeted therapies and advancing personalized medicine, paving the way for future research into GAS5-based treatment strategies in cancer.

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Publication Details

Journal
Cureus
Published
2025-01-16
DOI
https://doi.org/10.7759/cureus.77527
Citations
2
Primary Topic
Cancer-related molecular mechanisms research
Type
article
Field-Weighted Citation Impact
1.87
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article

The Multifaceted Role of lncRNA GAS5: A Pan-Cancer Analysis of Its Diagnostic, Prognostic, and Therapeutic Potential

Mohamed Alfaki, Sura O. Yousif, S. Awad, Asim Eisa et al.
2 citations
Cureus
Cancer-related molecular mechanisms research
1.87
article

The Multifaceted Role of lncRNA GAS5: A Pan-Cancer Analysis of Its Diagnostic, Prognostic, and Therapeutic Potential

Mohamed Alfaki, Sura O. Yousif, S. Awad, Asim Eisa, Mustafa A Abo-Alella, Hind Tarig I Yousif, Tasneem Dafaalla, Akif Dldom
article en
2 citations

Abstract

This comprehensive analysis across various cancers offers a significant foundation for GAS5 as a potential diagnostic and prognostic biomarker, especially prominent in LIHC, with additional relevance in KIRC. Identification of tissue-specific regulatory mechanisms and correlations with immune cells opens new perspectives into the context-dependent functionality of GAS5. These findings highlight the potential of GAS5 for developing targeted therapies and advancing personalized medicine, paving the way for future research into GAS5-based treatment strategies in cancer.

CureusVol. 17(1)
Nile Valley University (SD), National Centre for Research (Sudan) (SD), Sidra Medical and Research Center (QA), University of Bahri (SD), Karary University (SD), Red Sea University (SD)
Openalex Percentile: Top 17%
Cancer-related molecular mechanisms research
1.87
DOIOpen Access PDFOpenAlex
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The Multifaceted Role of lncRNA GAS5: A Pan-Cancer Analysis of Its Diagnostic, Prognostic, and Therapeutic Potential — Mohamed Alfaki, Sura O. Yousif, et al. · Cureus (2025) | TGRS Research Map | TGRS