ECM Modifications Driven by Age and Metabolic Stress Directly Promote Vascular Smooth Muscle Cell Osteogenic Processes
ECM modifications associated with aging and metabolic disease can directly induce osteogenic differentiation of VSMCs via distinct mechanisms and without the need for additional stimuli. This highlights the importance of the ECM microenvironment as a key driver of phenotypic modulation acting to accelerate age-associated vascular pathologies and provides a novel model system to study the mechanisms of calcification.
Authors
- Manuel Mayr (ORCID: https://orcid.org/0000-0002-0597-829X)
- Lukas Schmidt (ORCID: https://orcid.org/0000-0001-7565-1455)
- Susan Cox (ORCID: https://orcid.org/0000-0001-8322-1981)
- Meredith Whitehead (ORCID: https://orcid.org/0000-0002-2211-9673)
- Maria Faleeva (ORCID: https://orcid.org/0000-0003-4774-7833)
- Catherine M. Shanahan (ORCID: https://orcid.org/0000-0002-8352-8171)
- Rafael R. Oexner (ORCID: https://orcid.org/0009-0005-0959-601X)
Institutions
- King's College London (GB)
- British Heart Foundation (GB)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-01-16
- DOI
- https://doi.org/10.1161/atvbaha.124.321467
- Citations
- 6
- Primary Topic
- Connective tissue disorders research
- Type
- article
- Field-Weighted Citation Impact
- 10.90
Funders
- British Heart Foundation
- King's College London