Age- and sex-specific differences in myocardial sympathetic tone and left ventricular remodeling following myocardial injury
Testosterone associates with an increase in sympathetic tone, contributing to adverse cardiac remodeling following MI. Conversely, females maintain sympathetic integrity, independent of sex hormones. Our results suggest a biological advantage of female sex in post MI recovery. Further research is warranted to confirm these findings in humans.
Authors
- Ahmed Haider (ORCID: https://orcid.org/0000-0002-5204-4473)
- Linjing Mu (ORCID: https://orcid.org/0000-0001-5354-1546)
- Bruno Weber (ORCID: https://orcid.org/0000-0002-9089-0689)
- Sebastian Kozerke (ORCID: https://orcid.org/0000-0003-3725-8884)
- Fabrizio Montecucco (ORCID: https://orcid.org/0000-0003-0823-8729)
- Cathérine Gebhard (ORCID: https://orcid.org/0000-0001-7240-5822)
- Susan Bengs (ORCID: https://orcid.org/0000-0003-2424-3894)
- Philipp A. Kaufmann (ORCID: https://orcid.org/0000-0002-9451-5210)
- Simon M. Ametamey
- Sandro Fröhlich
- Dominik Etter (ORCID: https://orcid.org/0000-0002-7060-6089)
- Ronny R. Buechel (ORCID: https://orcid.org/0000-0001-8064-8904)
- Giovanni G. Camici (ORCID: https://orcid.org/0000-0002-0523-0695)
- Vera Regitz‐Zagrosek (ORCID: https://orcid.org/0000-0002-3566-3467)
- Monika Marędziak (ORCID: https://orcid.org/0000-0002-7281-9272)
- Alexander Akhmedov (ORCID: https://orcid.org/0000-0003-3052-9493)
- Geoffrey Warnock
- Claudia Keller (ORCID: https://orcid.org/0000-0001-7736-9680)
- Angela Portmann (ORCID: https://orcid.org/0000-0002-0973-5439)
Institutions
- Harvard University (US)
- University of Zurich (CH)
- University Hospital of Bern (CH)
- ETH Zurich (CH)
- Massachusetts General Hospital (US)
- Institute for Biomedical Engineering (CH)
- University Hospital of Zurich (CH)
- Ospedale Policlinico San Martino (IT)
- Charité - Universitätsmedizin Berlin (DE)
- University of Genoa (IT)
Publication Details
- Journal
- Biology of Sex Differences
- Published
- 2025-01-16
- DOI
- https://doi.org/10.1186/s13293-024-00673-5
- Citations
- 4
- Primary Topic
- Takotsubo Cardiomyopathy and Associated Phenomena
- Type
- article
- Field-Weighted Citation Impact
- 5.55
Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Olga Mayenfisch Stiftung
- UZH Foundation