Targeting Soluble Amyloid Oligomers in Alzheimer’s Disease: A Hypothetical Model Study Comparing Intrathecal Pseudodelivery of mAbs Against Intravenous Administration
Intrathecal pseudodelivery offers a promising alternative to IV mAbs, overcoming challenges associated with blood-brain barrier penetration and systemic side effects. Further research should focus on optimizing this approach and exploring combination therapies to enhance clinical outcomes in AD.
Authors
- Manuel Menéndez‐González (ORCID: https://orcid.org/0000-0002-5218-0774)
Institutions
- Universidad de Oviedo (ES)
- Hospital Universitario Central de Asturias (ES)
- Instituto de Investigación Sanitaria del Principado de Asturias (ES)
Publication Details
- Journal
- Diseases
- Published
- 2025-01-16
- DOI
- https://doi.org/10.3390/diseases13010017
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Instituto de Salud Carlos III