Association Between Local Skin Reactions and Efficacy with 5-Fluorouracil 4% Cream in Actinic Keratosis: A Post-Hoc Analysis of Two Randomised Clinical Trials
Our analysis showed that the severity of LSRs during 5-FU 4% treatment for AK was associated with a higher clearance rate. It appears that severe LSRs did not compromise treatment efficacy. Because LSRs can still be unpleasant, strategies must be developed to relieve patients to allow continued 5-FU 4% application.
Authors
- M. Groc
- Kilian Trin (ORCID: https://orcid.org/0000-0002-7650-645X)
- Nathalie Bégeault
- Markus V. Heppt (ORCID: https://orcid.org/0000-0003-4603-1825)
- Alain Delarue
- Anne-Cécile Mille
Institutions
- Université de Bordeaux (FR)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Universitätsklinikum Erlangen (DE)
- Pierre Fabre (France) (FR)
- Comprehensive Cancer Center Erlangen (DE)
Publication Details
- Journal
- Dermatology and Therapy
- Published
- 2025-01-16
- DOI
- https://doi.org/10.1007/s13555-024-01336-4
- Citations
- 3
- Primary Topic
- Nonmelanoma Skin Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.06