Janus Kinase 2/Signal Transducer and Activator of Transcription 3/Cyclooxygenase 2 Signaling Pathway Mediates the Effect of Central Angiotensin II on the Elevation of Rostral Ventrolateral Medulla Prostaglandin E <sub>2</sub> ‐Induced Oxidative Stres
Central Ang II induces the accumulation of RVLM PGE<sub>2</sub> through the neuronal AT1R (angiotensin type 1 receptor)/JAK2/STAT3/COX2 pathway, thereby promoting oxidative stress, augmenting sympathetic outflow, and contributing to essential hypertension.
Authors
- Weizhong Wang (ORCID: https://orcid.org/0000-0001-6979-4505)
- Yang‐Kai Wang (ORCID: https://orcid.org/0000-0002-7254-0335)
- Ji‐Kui Li
- Xing Tan (ORCID: https://orcid.org/0000-0002-1090-0438)
- Jie‐Fu Fan
- Yunqi Xiao
- Wen Wang
Institutions
- Second Military Medical University (CN)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-01-16
- DOI
- https://doi.org/10.1161/jaha.124.036762
- Citations
- 2
- Primary Topic
- Eicosanoids and Hypertension Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 2.22