Evidence of dissemination of a <i>clc</i> -type integrative and conjugative element to <i>Stenotrophomonas maltophilia</i> , mediating acquisition of <i>sul1</i> and other resistance determinants
A <i>Stenotrophomonas maltophilia</i> strain positive for the <i>bla</i><sub>VIM-1</sub> metallo-beta-lactamase gene and resistant to trimethoprim-sulfamethoxazole was unexpectedly isolated from a surveillance rectal swab. The characterization of the strain revealed carriage of a 91 kb integrative and conjugative element (ICE) harboring several resistance determinants [<i>sul1</i>, <i>bla</i><sub>VIM-1</sub>, <i>aac(6')-Ib</i>, <i>aac(6')-31</i>, <i>qacE</i>∆<i>1</i>, <i>cld</i>, and <i>merEDAPTR</i>], closely related with a group of <i>clc</i>-type ICEs widespread among <i>Pseudomonas aeruginosa</i> and other pseudomonads. Results highlighted the possible spreading of similar elements to <i>S. maltophilia</i>, mediating the acquisition of relevant resistances.
Authors
- Gian María Rossolini (ORCID: https://orcid.org/0000-0002-9386-0434)
- Maria Grazia Cusi (ORCID: https://orcid.org/0000-0001-8869-8164)
- Vincenzo Di Pilato (ORCID: https://orcid.org/0000-0002-5863-5805)
- Selene Rebecca Boncompagni
- Eleonora Riccobono (ORCID: https://orcid.org/0000-0003-2415-5077)
Institutions
- University of Siena (IT)
- Ospedale Policlinico San Martino (IT)
- University of Florence (IT)
- University of Genoa (IT)
Publication Details
- Journal
- Antimicrobial Agents and Chemotherapy
- Published
- 2025-01-16
- DOI
- https://doi.org/10.1128/aac.01554-24
- Citations
- 3
- Primary Topic
- Infections and bacterial resistance
- Type
- article
- Field-Weighted Citation Impact
- 5.39