Association between the <i>ABCC11</i> gene polymorphism-determined earwax properties and external auditory canal microbiota in healthy adults
The <i>ABCC11</i> gene polymorphism, which determines earwax characteristics, regulates the composition of the ear canal microbiota and its metabolic pathways. We determined the presence of genome-microbiome interactions in the resident microbiota of the ear canal. Future studies should focus on <i>ABCC11</i> gene polymorphisms to elucidate the pathogenesis of ear diseases and develop therapeutic methods.
Authors
- Takehiko Sambe (ORCID: https://orcid.org/0000-0001-6730-7873)
- Toshiaki Tsurui (ORCID: https://orcid.org/0000-0002-6167-8953)
- Eiji Funayama
- Kiyoshi Yoshimura (ORCID: https://orcid.org/0000-0003-4816-1826)
- Atsushi Ishida (ORCID: https://orcid.org/0000-0003-0620-5819)
- Atsuo Kuramasu
- Kakei Ryu (ORCID: https://orcid.org/0000-0002-9800-9198)
- Yuki Azetsu
- Naoki Uchida (ORCID: https://orcid.org/0000-0002-4220-9625)
- Y Yoshizawa
- Sumito Kumagai
- Sakiko Yasuhara
- Yasunobu Amari
- Junya Isobe
- Takuya Mizukami (ORCID: https://orcid.org/0000-0003-1086-8746)
- Yuki Maruyama (ORCID: https://orcid.org/0000-0003-2695-1472)
- Sei Kobayashi
- Masahiro Hosonuma (ORCID: https://orcid.org/0000-0002-5861-7543)
- Ryota Nakano (ORCID: https://orcid.org/0000-0002-9840-2416)
- Tatsuya Nakanishi
- Satoshi Mochizuki (ORCID: https://orcid.org/0000-0003-4862-5926)
- Aya Sasaki
- Yutaka Sano
- Tatsunori Oguchi
- Kohei Tajima
- Yoshitaka Yamazaki
Institutions
- Nihon University (JP)
- SHOWA Medical University (JP)
- Tokai University (JP)
- Therapeutics Clinical Research (US)
- SHOWA Medical University Fujigaoka Hospital (JP)
- SHOWA Medical University Hospital (JP)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2025-01-16
- DOI
- https://doi.org/10.1128/spectrum.01698-24
- Citations
- 2
- Primary Topic
- Ear Surgery and Otitis Media
- Type
- article
- Field-Weighted Citation Impact
- 3.70
Funders
- Showa University