Gut microbial dysbiosis, IgA, and Enterococcus in common variable immunodeficiency with immune dysregulation
This study further supports the hypothesis that a dysregulated gut microbiota, with IgA deficiency as an important driving factor, contributes to systemic inflammation in primary antibody deficiency, and introduces enterococci as potential pathobionts in CVIDid. Video Abstract.
Authors
- Joris M. van Montfrans (ORCID: https://orcid.org/0000-0001-6764-0211)
- P. Martin van Hagen
- Pauline M. Ellerbroek
- Femke van Wijk (ORCID: https://orcid.org/0000-0001-8343-1356)
- Virgil A. S. H. Dalm (ORCID: https://orcid.org/0000-0001-5945-4435)
- Lodewijk A.A. Brosens (ORCID: https://orcid.org/0000-0003-1341-8994)
- Martine van Stigt Thans
- Jaap Schuurmans (ORCID: https://orcid.org/0000-0001-7471-8304)
- Marlot van der Wal (ORCID: https://orcid.org/0000-0003-4554-9059)
- Hae‐Won Uh (ORCID: https://orcid.org/0000-0003-4195-7872)
- Fernanda L. Paganelli (ORCID: https://orcid.org/0000-0001-9990-9203)
- Remi M. M. Vanmaris
- Helen L. Leavis (ORCID: https://orcid.org/0000-0001-8720-3684)
- Moniek Salomons
- Annick A. J. M. van de Ven (ORCID: https://orcid.org/0000-0001-9816-8634)
- Marco C. Viveen
- Malbert R. C. Rogers
- Roos-Marijn Berbers
- Rob J. L. Willems (ORCID: https://orcid.org/0000-0002-7370-0812)
Institutions
- University Medical Center Groningen (NL)
- Utrecht University (NL)
- Erasmus MC (NL)
- University Medical Center Utrecht (NL)
Publication Details
- Journal
- Microbiome
- Published
- 2025-01-16
- DOI
- https://doi.org/10.1186/s40168-024-01982-y
- Citations
- 10
- Primary Topic
- Immunodeficiency and Autoimmune Disorders
- Type
- article
- Field-Weighted Citation Impact
- 7.97
Funders
- Rijksuniversiteit Groningen
- Universitair Medisch Centrum Utrecht
- Stichting Zeldzame Ziekten Fonds