Pre-clinical safety studies of intranasal virus-like particles based vaccine for prevention of COVID-19
The VLP vaccine is safe, as evidenced by the results of preclinical studies, does not negatively affect the function of various organs, the level of cellular and biochemical biomarkers in the blood and urine of mice and rats. Visual assessment, cytology and histology of the vaccine injection site did not reveal any local irritant effect.
Authors
- A. P. Malkova (ORCID: https://orcid.org/0000-0002-2817-4817)
- Т. В. Гребенникова (ORCID: https://orcid.org/0000-0002-6141-9361)
- Olesja Eliseeva (ORCID: https://orcid.org/0000-0002-0723-9749)
- Valeria M. Kondratieva (ORCID: https://orcid.org/0000-0001-9163-4516)
- Yana Yu. Chernoryzh (ORCID: https://orcid.org/0000-0001-9848-8515)
- Tatyana E. Savochkina (ORCID: https://orcid.org/0000-0003-4366-8476)
- O. N. Zaykova (ORCID: https://orcid.org/0000-0003-4708-2069)
- Oleg Latyshev (ORCID: https://orcid.org/0000-0002-5757-3809)
- Dmitriy Yu. Yakunin
- Ekaterina S. Sludnyakova
Institutions
- Ministry of Health of the Russian Federation (RU)
Publication Details
- Journal
- Problems of Virology
- Published
- 2025-01-16
- DOI
- https://doi.org/10.36233/0507-4088-278
- Citations
- 4
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 5.58