Analysis of the association of influenza clinical course with single nucleotide polymorphisms in genes affecting the interferon-λ3 production
Genetic markers of increased risk of community-acquired pneumonia in influenza include the presence of the T allele in <i>IFNL4</i> gene (rs12979860 C/T) and, to a lesser extent, the G allele in <i>IFNL3</i> gene (rs8099917 T/G). Patients carrying these alleles have an increased risk of developing pneumonia, especially in old age.
Authors
- Irina N. Khlopova (ORCID: https://orcid.org/0000-0002-7419-590X)
- Burtseva Ei (ORCID: https://orcid.org/0000-0003-2518-6801)
- Maya D. Stuchinskaya (ORCID: https://orcid.org/0000-0001-8544-7482)
- С. В. Трушакова (ORCID: https://orcid.org/0000-0002-9610-3041)
- K. G. Krasnoslobodtsev (ORCID: https://orcid.org/0000-0003-1745-9128)
- Л. И. Николаева (ORCID: https://orcid.org/0000-0002-1323-5568)
- Л. В. Колобухина (ORCID: https://orcid.org/0000-0001-5775-3343)
- Victor V. Kuprianov (ORCID: https://orcid.org/0000-0002-8602-1974)
- N. Shevchenko (ORCID: https://orcid.org/0000-0002-2486-4554)
- Е. А. Мукашева (ORCID: https://orcid.org/0000-0002-5688-5309)
- Л. Б. Кистенева (ORCID: https://orcid.org/0000-0001-7336-409X)
- И. С. Кружкова (ORCID: https://orcid.org/0000-0002-1983-481X)
- Kristina P. Telepenina
Institutions
- Ministry of Health of the Russian Federation (RU)
Publication Details
- Journal
- Problems of Virology
- Published
- 2025-01-16
- DOI
- https://doi.org/10.36233/0507-4088-271
- Primary Topic
- Influenza Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00