Achieving High‐Precision Attenuation Coefficient Measurement in Optical Coherence Tomography
In this study, we aim to validate the analytical Cramer-Rao lower bound (CRLB) equation for determining attenuation coefficients using a 1310 nm Optical Coherence Tomography (OCT) system. Our experimental results successfully confirm the validity of the equation, achieving unprecedented precision with a standard deviation below 0.01 mm<sup>-1</sup> for intralipid samples. Furthermore, we introduce a systematic framework for attaining high precision in OCT attenuation measurements.
Authors
- Ton G. van Leeuwen (ORCID: https://orcid.org/0000-0002-5642-1133)
- Linda B. Neubrand (ORCID: https://orcid.org/0000-0003-4145-2954)
- Xavier Attendu (ORCID: https://orcid.org/0000-0002-7625-1346)
Institutions
- Amsterdam University College (NL)
- Amsterdam Neuroscience (NL)
- Amsterdam University Medical Centers (NL)
- Institute for Atherosclerosis Research (RU)
- Cancer Center Amsterdam (NL)
- Polytechnique Montréal (CA)
- Amsterdam University of Applied Sciences (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Journal of Biophotonics
- Published
- 2025-01-16
- DOI
- https://doi.org/10.1002/jbio.202400395
- Primary Topic
- Optical Coherence Tomography Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Strong
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek