Distinct Molecular and Clinical Features of Specific Variants of KRAS Codon 12 in Pancreatic Adenocarcinoma
KRAS G12D tumors exhibited a distinct molecular profile compared with G12R tumors, including genes involved in the MAPK pathway, immune activation, and glucose and glutamine metabolism. Patients with G12D mutations had lower OS compared with those with G12R. Based on these data, future studies should address the KRAS mutation status and explore distinct therapeutic vulnerabilities.
Authors
- Jashodeep Datta (ORCID: https://orcid.org/0000-0003-2869-1571)
- Anup Kasi (ORCID: https://orcid.org/0000-0002-4305-5701)
- Rachna T. Shroff (ORCID: https://orcid.org/0000-0003-0066-2672)
- Michael J. Pishvaian (ORCID: https://orcid.org/0000-0002-1165-9041)
- Andrew Hinton (ORCID: https://orcid.org/0009-0000-2744-9308)
- Sanjay Goel (ORCID: https://orcid.org/0000-0002-2798-7568)
- Aaron Ciner (ORCID: https://orcid.org/0000-0002-5656-0758)
- Harshabad Singh (ORCID: https://orcid.org/0000-0001-6295-2013)
- Bach Ardalan (ORCID: https://orcid.org/0000-0003-3950-1710)
- Emil Lou (ORCID: https://orcid.org/0000-0002-1607-1386)
- Sourat Darabi (ORCID: https://orcid.org/0000-0002-3395-894X)
- Yasmine Baca (ORCID: https://orcid.org/0000-0003-2130-0611)
- Anthony F. Shields (ORCID: https://orcid.org/0000-0002-9122-1014)
- Andrew J. Aguirre (ORCID: https://orcid.org/0000-0002-0701-6203)
- Jose Ignacio Azqueta
- Joanne Xiu (ORCID: https://orcid.org/0000-0001-8744-5827)
Institutions
- Rutgers, The State University of New Jersey (US)
- University of Maryland, Baltimore (US)
- University of Minnesota (US)
- Hoag Memorial Hospital Presbyterian (US)
- University of Arizona (US)
- Johns Hopkins University (US)
- University of Miami (US)
- Johns Hopkins Medicine (US)
- University of Minnesota System (US)
- The Barbara Ann Karmanos Cancer Institute (US)
- The University of Kansas Cancer Center (US)
- University of Miami Health System (US)
- Phoenix (United States) (US)
- Dana-Farber Cancer Institute (US)
- University of Kansas Medical Center (US)
- Caris Life Sciences (United States) (US)
- Sylvester Comprehensive Cancer Center (US)
- University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center
- University of Baltimore (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-01-16
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-3149
- Citations
- 14
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 14.64
Funders
- Bristol-Myers Squibb
- Eli Lilly and Company
- AstraZeneca
- GlaxoSmithKline
- Celgene
- FibroGen
- Boston Scientific Corporation
- Taiho Pharmaceutical
- Exelixis
- Novocure
- Five Prime Therapeutics
- Mirati Therapeutics
- Incyte
- NuCana
- NGM Biopharmaceuticals
- Revolution Medicines
- Seagen
- Natera
- Eisai
- Astellas Pharma
- Servier
- Ipsen
- Bavarian Nordic
- Geistlich Pharma
- Genentech
- Daiichi Sankyo Europe