Targeting MXD1 sensitises pancreatic cancer to trametinib

Our study has discovered an important mechanism for trametinib resistance and identified MXD1 as a druggable target in treatment of trametinib-resistant PDAC.

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Publication Details

Journal
Gut
Published
2025-01-16
DOI
https://doi.org/10.1136/gutjnl-2024-333408
Citations
4
Primary Topic
Cancer Mechanisms and Therapy
Type
article
Field-Weighted Citation Impact
5.89

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article

Targeting MXD1 sensitises pancreatic cancer to trametinib

Shaoqiu Liu, Hongzhe Zhao, Sihan Zhao, Yifan Zhou et al.
4 citations
Gut
Cancer Mechanisms and Therapy
5.89
article

Targeting MXD1 sensitises pancreatic cancer to trametinib

Shaoqiu Liu, Hongzhe Zhao, Sihan Zhao, Yifan Zhou, Lingxing Zeng, Jian Zheng, Xiaoyu Wu, Chunling Xue, Ziming Chen, Ruihong Bai, Ji Liu, Jialiang Zhang, Dongxin Lin, Shuang Liu, Shaojia Wu, Zilan Xu, Shaoping Zhang, Xudong Huang, Shuang Deng, Mei Li, Xinyi Peng
article en
4 citations

Abstract

Our study has discovered an important mechanism for trametinib resistance and identified MXD1 as a druggable target in treatment of trametinib-resistant PDAC.

GutVol. 74(8)
Sun Yat-sen University (CN), Chinese Academy of Medical Sciences & Peking Union Medical College (CN), Sun Yat-sen University Cancer Center (CN), Nanjing Medical University (CN), Guangzhou Medical University (CN)
National Natural Science Foundation of China
Good health and well-being
Openalex Percentile: Top 5%
Cancer Mechanisms and Therapy
5.89
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Targeting MXD1 sensitises pancreatic cancer to trametinib — Shaoqiu Liu, Hongzhe Zhao, et al. · Gut (2025) | TGRS Research Map | TGRS