Targeting MXD1 sensitises pancreatic cancer to trametinib
Our study has discovered an important mechanism for trametinib resistance and identified MXD1 as a druggable target in treatment of trametinib-resistant PDAC.
Authors
- Shaoqiu Liu (ORCID: https://orcid.org/0009-0002-5149-6045)
- Hongzhe Zhao (ORCID: https://orcid.org/0009-0005-9859-0452)
- Sihan Zhao (ORCID: https://orcid.org/0000-0002-1236-2274)
- Yifan Zhou (ORCID: https://orcid.org/0009-0000-9174-8169)
- Lingxing Zeng (ORCID: https://orcid.org/0000-0002-0846-8762)
- Jian Zheng (ORCID: https://orcid.org/0000-0001-9831-7038)
- Xiaoyu Wu (ORCID: https://orcid.org/0000-0003-3376-5643)
- Chunling Xue (ORCID: https://orcid.org/0009-0007-9616-004X)
- Ziming Chen (ORCID: https://orcid.org/0000-0001-5987-0148)
- Ruihong Bai (ORCID: https://orcid.org/0009-0001-0050-9152)
- Ji Liu (ORCID: https://orcid.org/0000-0003-2496-9521)
- Jialiang Zhang (ORCID: https://orcid.org/0000-0003-1626-6674)
- Dongxin Lin (ORCID: https://orcid.org/0000-0002-8723-8868)
- Shuang Liu (ORCID: https://orcid.org/0000-0003-2347-413X)
- Shaojia Wu
- Zilan Xu (ORCID: https://orcid.org/0009-0006-0915-8076)
- Shaoping Zhang (ORCID: https://orcid.org/0000-0003-3364-7110)
- Xudong Huang (ORCID: https://orcid.org/0000-0002-5587-4448)
- Shuang Deng (ORCID: https://orcid.org/0009-0009-4025-0788)
- Mei Li (ORCID: https://orcid.org/0009-0000-8513-3117)
- Xinyi Peng
Institutions
- Sun Yat-sen University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Sun Yat-sen University Cancer Center (CN)
- Nanjing Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Gut
- Published
- 2025-01-16
- DOI
- https://doi.org/10.1136/gutjnl-2024-333408
- Citations
- 4
- Primary Topic
- Cancer Mechanisms and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 5.89
Funders
- National Natural Science Foundation of China