Safety, Tolerability, and Pharmacokinetics of Long-Acting Broadly Neutralizing HIV-1 Monoclonal Antibody VRC07–523LS in Newborn Infants Exposed to HIV-1
VRC07-523LS was well tolerated with pharmacokinetics that support further studies of potent long-acting bNAbs together with antiretrovirals to prevent HIV-1 acquisition in infants.
Authors
- Frederic Bone
- Elizabeth J. McFarland (ORCID: https://orcid.org/0000-0003-0653-8955)
- Kwang Low
- Petronella Muresan
- Jaime G. Deville (ORCID: https://orcid.org/0000-0002-7523-0658)
- Hans Spiegel (ORCID: https://orcid.org/0000-0001-9552-789X)
- Nicole H. Tobin (ORCID: https://orcid.org/0000-0001-6904-6128)
- Edmund V. Capparelli (ORCID: https://orcid.org/0000-0002-1630-0505)
- Benjamin Johnston
- Murli Purswani (ORCID: https://orcid.org/0000-0001-6902-7779)
- Carrie Chambers
- Coleen K. Cunningham (ORCID: https://orcid.org/0000-0002-7725-3052)
- Hilda Mujuru (ORCID: https://orcid.org/0000-0003-1615-3856)
- Dwight E. Yin (ORCID: https://orcid.org/0000-0002-8599-1004)
- Sai Majji
- Lúcio Gama (ORCID: https://orcid.org/0000-0001-9511-012X)
- Jack Moye (ORCID: https://orcid.org/0000-0001-9976-8586)
- Emily Brown
- Lynette Purdue
- Gerhard Barnard Theron (ORCID: https://orcid.org/0000-0001-8888-1436)
- Charlotte Perlowski
- Grace Alvarez
- Paul A. Harding
Institutions
- Family Health International 360 (US)
- National Institutes of Health (US)
- Children's Hospital of Orange County (US)
- Mount Sinai Health System (US)
- University of Miami (US)
- University of Zimbabwe (ZW)
- University of California, Los Angeles (US)
- University of California, Irvine (US)
- Stellenbosch University (ZA)
- University of California San Diego (US)
- University of California, Irvine Medical Center (US)
- National Institute of Allergy and Infectious Diseases (US)
- Frontier Science & Technology Research Foundation, Inc. (US)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (US)
- University of Colorado Anschutz Medical Campus (US)
- University of Montana (US)
- Kelly Services (United States) (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Journal of the Pediatric Infectious Diseases Society
- Published
- 2025-01-16
- DOI
- https://doi.org/10.1093/jpids/piaf002
- Citations
- 6
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 6.22