Quantification of solvation forces with amplitude modulation AFM

The proposed matrix-based FRM, differently from standard FRMs, can reconstruct the full SLI interaction at the atomic scale, with no loss of information deriving from the specific choice of AFM experimental parameters or the force functional form. This method unlocks the full spectrum of physical phenomena encoded in the tip-sample interaction at the SLI in AFM experiments, greatly advancing our understanding of interfacial properties and their effects on colloid science, including nanoparticle interactions and molecular self-assembly.