Impaired Presynaptic Function Contributes Significantly to the Pathology of Glycine Receptor Autoantibodies
In summary, our study is the first to implicate presynaptic defects in the pathophysiology of autoimmune diseases such as SPS and PERM, which are associated with GlyR aAbs. Individually tuned binding preferences for presynaptic and postsynaptic targets thus underlie the rather diverse appearance of clinical symptoms and different therapeutic responses in patients suffering from GlyR autoimmunity.
Authors
- Fang Zheng (ORCID: https://orcid.org/0000-0002-5699-8063)
- Christian Werner (ORCID: https://orcid.org/0000-0003-1281-0919)
- Claudia Sommer (ORCID: https://orcid.org/0000-0002-7064-5002)
- Christian Alzheimer (ORCID: https://orcid.org/0000-0003-3910-5072)
- Carmen Villmann (ORCID: https://orcid.org/0000-0003-1498-6950)
- Erdem Tüzün (ORCID: https://orcid.org/0000-0002-4483-0394)
- Anna-Lena Wiessler (ORCID: https://orcid.org/0000-0002-2039-3919)
- Margarita Habib (ORCID: https://orcid.org/0009-0004-2894-5572)
Institutions
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- University of Würzburg (DE)
- Universitätsklinikum Würzburg (DE)
- Istanbul University (TR)
Publication Details
- Journal
- Neurology Neuroimmunology & Neuroinflammation
- Published
- 2025-01-16
- DOI
- https://doi.org/10.1212/nxi.0000000000200364
- Citations
- 6
- Primary Topic
- Autoimmune Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 8.34