Prevalence of Fatigue and Associations With Depression and Cognitive Impairment in Patients With CADASIL
Fatigue was present in over half of the patients with CADASIL. Depression and cognition were the main predictors of fatigue, and all 3 symptoms were frequently comorbid. The relationship between depression and fatigue was the strongest and was bidirectional. This suggests targeting depressive symptoms may have benefit in fatigue management.
Authors
- Stanley Anyanwu (ORCID: https://orcid.org/0000-0001-7081-4462)
- Hugh S. Markus (ORCID: https://orcid.org/0000-0002-9794-5996)
- Fatemeh Koohi (ORCID: https://orcid.org/0000-0003-1326-8594)
- Amy A. Jolly (ORCID: https://orcid.org/0000-0003-2669-4998)
- Robin G. Morris (ORCID: https://orcid.org/0000-0001-7767-5258)
Institutions
- King's College London (GB)
- University of Cambridge (GB)
Publication Details
- Journal
- Neurology
- Published
- 2025-01-16
- DOI
- https://doi.org/10.1212/wnl.0000000000213335
- Citations
- 9
- Primary Topic
- Cerebrovascular and genetic disorders
- Type
- article
- Field-Weighted Citation Impact
- 12.50
Funders
- National Institute for Health and Care Research
- British Heart Foundation
- Department of Health and Social Care
- University of Cambridge
- University College London
- Cambridge University Hospitals
- University College London Hospitals NHS Foundation Trust
- Dementias Platform UK
- Medical Research Council