Easily Accessible and Solution‐Stable Ni(0) Precatalysts for High‐Throughput Experimentation
We report the synthesis, characterization, and catalytic applications of N,N'-diaryl diazabutadiene (DAB) Ni(0) complexes stabilized by alkene ligands. These complexes are soluble and stable in several organic solvents, making them ideal candidates for in situ catalyst formation during high-throughput experimentation (HTE). We used HTE to evaluate these Ni(0) precatalysts in a variety of Suzuki and C-N coupling reactions, and they were found to have equal or better performance than the still-standard Ni(0) source, Ni(COD)<sub>2</sub>.
Authors
- David C. Leitch (ORCID: https://orcid.org/0000-0002-8726-3318)
- Charles Killeen (ORCID: https://orcid.org/0000-0003-4901-3673)
- Nahiane Pipaón Fernández
- Gilian T. Thomas (ORCID: https://orcid.org/0000-0002-1468-2714)
- Odhran Cruise (ORCID: https://orcid.org/0009-0002-3473-0741)
- Daelin Peel-Smith
Institutions
- University of Victoria (CA)
Publication Details
- Journal
- Chemistry - A European Journal
- Published
- 2025-01-16
- DOI
- https://doi.org/10.1002/chem.202403960
- Citations
- 1
- Primary Topic
- Machine Learning in Materials Science
- Type
- article
- Field-Weighted Citation Impact
- 0.52
Funders
- National Science Foundation
- Bill and Melinda Gates Foundation
- University of Rochester
- Center for Enabling New Technologies Through Catalysis
- Division of Chemistry