Controlling the stability of monodisperse phospholipid-coated microbubbles by tuning their buckling pressure
Quasi-static compression of a microbubble above its buckling pressure leads to its destabilization. Lowering the PEG molar fraction from 10 to 1.5% increased the buckling pressure from 3 kPa to 27 kPa. Similarly, heating the 10 mol% bubble suspension at 60<sup>∘</sup>C for one hour raised the buckling pressure by 20 kPa, due to the selective loss of PEGylated lipid from the shell, without affecting the monodispersity of the bubbles. The higher buckling pressure significantly improved microbubble stability, allowing them to withstand pressurization cycles of up to 45 kPa, nearly three times the systolic blood pressure in vivo.
Authors
- Tim Segers (ORCID: https://orcid.org/0000-0001-5428-1547)
- Michel Versluis (ORCID: https://orcid.org/0000-0002-2296-1860)
- Guillaume Pierre René Lajoinie (ORCID: https://orcid.org/0000-0002-8226-7301)
- Samir Cherkaoui (ORCID: https://orcid.org/0000-0001-8868-3245)
- Benjamin van Elburg (ORCID: https://orcid.org/0000-0003-0946-4752)
- Anne Lassus
Institutions
- Bracco (Switzerland) (CH)
- Max Planck University of Twente Center for Complex Fluid Dynamics (NL)
- University of Twente (NL)
Publication Details
- Journal
- Journal of Colloid and Interface Science
- Published
- 2025-01-16
- DOI
- https://doi.org/10.1016/j.jcis.2025.01.114
- Citations
- 6
- Primary Topic
- Ultrasound and Hyperthermia Applications
- Type
- article
- Field-Weighted Citation Impact
- 4.04
Funders
- European Commission
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek