Amino Acids and CART Distinguish A−β+ Ketosis-Prone Diabetes From Type 1 and Type 2 Diabetes During Hyperglycemic Crises
During DKA, KPD and T1D patients have similarly altered amino acid profiles that differentiate them from T2D patients. Elevated protein catabolic hormones drive altered amino acid metabolism in KPD, rather than insulin deficiency as with T1D. A combination of 6 analytes differentiates KPD from T1D and T2D during hyperglycemic crises.
Authors
- Kelly Rogers Keene
- Jinyoung Byun (ORCID: https://orcid.org/0000-0001-8579-1435)
- Jean W. Hsu (ORCID: https://orcid.org/0000-0002-5666-3132)
- Åke Lernmark (ORCID: https://orcid.org/0000-0003-1735-0499)
- Ashok Balasubramanyam (ORCID: https://orcid.org/0000-0003-2093-5201)
- W. Frank Peacock (ORCID: https://orcid.org/0000-0002-2730-6742)
- Danielle Guffey (ORCID: https://orcid.org/0000-0003-3721-614X)
- Xiaofang Huang (ORCID: https://orcid.org/0000-0003-1090-8349)
- Mustafa Tosur (ORCID: https://orcid.org/0000-0002-2111-271X)
- Rasmus Bennet
- Farook Jahoor
Institutions
- Baylor College of Medicine (US)
- Lund University (SE)
- Ben Taub Hospital (US)
- Harris Health System (US)
- Houston Institute for Clinical Research (US)
- Children's Nutrition Research Center at Baylor College of Medicine (US)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2025-01-16
- DOI
- https://doi.org/10.1210/clinem/dgaf033
- Citations
- 1
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 1.16