Isogenic Transplantation of Hybrid Artificial Pleural Tissue Consisting of Rat Cells and Polyglycolic Acid Nanofiber Sheet Induces Restoration of Mesothelial Defects in Rat Model
Successful isogenic engraftment of H-APLTs was achieved in a rat model of pleural defects. The combination of accumulated fibroblasts and collagen-coated PGA nanofiber sheets contributed to the maintenance of the mesothelial layer's structure and function, potentially preventing air leaks and intrathoracic adhesions.
Authors
- Masahito Minakawa
- Daisuke Kimura (ORCID: https://orcid.org/0000-0002-5484-8686)
- Chengyang Song (ORCID: https://orcid.org/0009-0008-0749-568X)
- Yoshiya Asano (ORCID: https://orcid.org/0000-0002-8941-7659)
- Kengo Tani (ORCID: https://orcid.org/0000-0003-3218-3895)
- Hiroshi Shimoda (ORCID: https://orcid.org/0000-0002-6871-3715)
Institutions
- Hirosaki University (JP)
- Fourth Affiliated Hospital of China Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Artificial Organs
- Published
- 2025-01-16
- DOI
- https://doi.org/10.1111/aor.14947
- Primary Topic
- Tissue Engineering and Regenerative Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Foundation
- Japan Society for the Promotion of Science