METABOLIC STUDIES OF BREAST CANCER (REVIEW)

Metabolomics is a new approach in modern biomedical science, the purpose of which is to study unique chemicals specific to the processes occurring in living cells. Due to the continuous development of advanced analytical methods and bioinformatics, metabolomics is widely used as a new, holistic, diagnostic tool in clinical and biomedical research. Metabolic reprogramming is a hallmark of cancer. Studies have shown that in transformed cells, in-cluding the mammary gland, there are profound metabolic changes aimed at survival. The detection of oncometabolites is one of the important prob-lems of modern science today, as it allows understanding the metabolic pathways of the transformed cell, which is important both for diagnosis and the search for new therapeutic targets. In connection with the development of new chemical technologies, it became possible to determine the level of steroids and their metabolites, as well as fatty acids in the tumor. One such method, along with NMR spectrometry and liquid chromatography, in con-junction with mass spectrometry (LC-MS), is gas chromatography with GC-MS mass spectrometry. Enormous progress in the application of these modern analytical methods allows for a deeper and more accurate description of metabolic processes. This review article discusses some of the current and current hurdles in cancer metabolomics research. In addition, it reviews some of the most re-cent and exciting developments in metabolomics that may address some of these issues. The purpose of this article is to inform the oncometabo-lomics research community about the problems and possible solutions to these problems.