Anticancer activity of Diplocyclos palmatus (L.) C. Jeffrey fruit on HCT116 cell line

India is the richest biodiversity country, having various varieties of medicinal plants, also connected to resulting medicines, are used in traditional medicine.Diplocyclos palmatus (L.) C. Jeffrey is a wild medicinally significant plant, a member of Cucurbitaceae.The current examination was to observe and record the result of the anticancer study of wild D. palmatus fruit, was subjected to a drying method (tray drying) using ethanolic solvent for extraction.MTT assay and apoptosis study of ethanolic extract of the fruit D. palmatus was tested against HCT116 cell line at various concentrations at three varied period, viz., 24, 48, and 72 h.The outcomes exhibited that ethanolic solvent extract of the fruit of D. palmatus constrained the growth of HCT116 cells of 69.58 g/ml at IC 50 concentration, respectively.Alternation in the cell morphology also revealed that D. palmatus comprises a few valuable chemical elements extracted using ethanol that can be used further in the management of cancer treatment.

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Publication Details

Journal
Annals of Phytomedicine An International Journal
Published
2024-12-01
DOI
https://doi.org/10.54085/ap.2024.13.2.50
Primary Topic
Cancer Treatment and Pharmacology
Type
article
Field-Weighted Citation Impact
0.00

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article

Anticancer activity of Diplocyclos palmatus (L.) C. Jeffrey fruit on HCT116 cell line

B. R. Ramya, S. Leelavathi
Annals of Phytomedicine An International Journal
Cancer Treatment and Pharmacology
article

Anticancer activity of Diplocyclos palmatus (L.) C. Jeffrey fruit on HCT116 cell line

B. R. Ramya, S. Leelavathi
article en

Abstract

India is the richest biodiversity country, having various varieties of medicinal plants, also connected to resulting medicines, are used in traditional medicine.Diplocyclos palmatus (L.) C. Jeffrey is a wild medicinally significant plant, a member of Cucurbitaceae.The current examination was to observe and record the result of the anticancer study of wild D. palmatus fruit, was subjected to a drying method (tray drying) using ethanolic solvent for extraction.MTT assay and apoptosis study of ethanolic extract of the fruit D. palmatus was tested against HCT116 cell line at various concentrations at three varied period, viz., 24, 48, and 72 h.The outcomes exhibited that ethanolic solvent extract of the fruit of D. palmatus constrained the growth of HCT116 cells of 69.58 g/ml at IC 50 concentration, respectively.Alternation in the cell morphology also revealed that D. palmatus comprises a few valuable chemical elements extracted using ethanol that can be used further in the management of cancer treatment.

Annals of Phytomedicine An International JournalVol. 13(2)
University of Mysore
Zero hunger
Openalex Percentile: Top 58%
Cancer Treatment and Pharmacology
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