Development of a novel self-nanoemulsifying drug delivery system (SNEDDS) for enhanced efficacy of bedaquiline

The clinical use of bedaquiline (BDQ) for treating MDR-TB is limited due to its poor dissolution and oral bioavailability.The bedaquiline-loaded self-nanoemulsifying drug delivery system (BDQ-SNEDDS) was prepared by simple admixture method.Based on maximum drug solubility, capryol 90, cremophor EL, and carbitol were chosen as the components for the self-nanoemulsifying drug delivery system (SNEDDS) formulation.Six formulations were prepared and optimized using various ratios of the selected excipients, including distilled water as the aqueous phase.Dynamic light scattering (DLS) results showed that the optimized formulations F1-F6 had particle sizes under 200 nm after 11 h of stirring.Bedaquiline loaded SNEDDS had a negative zeta potential of -21.16 3.4 mV.Furthermore, above formulations were subjected to stability study and consequently formulation F5 was selected for further analysis due to its demonstrated stability.The inhibition diameter zones obtained by the well diffusion method for Escherichia coli and Pseudomonas aeruginosa demonstrated notable antibacterial activity of the BDQ-SNEDDS formulation.SNEDDS could be a potential candidate for enhanced efficacy of bedaquiline.