Hepatoprotective potential of curcumin loaded Avocado oil-based nanoemulsion system

Avocado oil (AO), an edible oil possesses enriched antioxidant activity and potential to modulate drug permeability.AO an advantageous base for a nanoemulsion delivery platform, especially for poorly watersoluble drugs or drugs with impaired permeability.Present study describes the development and AO-based curcumin nanoemulsion (NE) to address curcumin's poor bioavailability and assessment of hepatoprotective efficacy Optimized curcumin nanoemulsion formulation (F5), was characterized for pH, encapsulation efficiency and droplet size.Antioxidant capacity of (F5) was assessed using DPPH radical scavenging activity, demonstrated free radical neutralization.Assessment of hepatoprotective studies at low-dose (NELD: 10 mg/kg) and high-dose (NEHD: 20 mg/kg) nanoemulsion treatments against CCl 4 -induced hepatotoxicity.NEHD significantly mitigated CCl 4 -induced hepatotoxicity, demonstrated hepatoprotective effect amongst all groups.NEHD treatment led to a notable reduction in liver biomarkers and preserved liver histology, surpassing the efficacy of conventional curcumin doses.Histological analysis showed that inflammation and cellular damage observed in the NEHD were recovered and supports protective role against oxidative liver damage.These findings suggest that high-dose AO-based curcumin nanoemulsion enhances curcumin's bioavailability and therapeutic action, making it a promising candidate for liver protection.This study underscores the potential of nanoemulsion delivery systems in maximizing curcumin's clinical benefits for hepatoprotection.