Novel Approaches to Monitor Pharmacokinetics and Metabolism of Gemcitabine-Ibandronate Conjugate in Mice and Dogs
Pharmacokinetic studies in dogs and mice showed that GEM-IB is rapidly converted to IB and GEM; dFdU is formed (from GEM) with a delay. The rapid disappearance of GEM-IB from circulation could be explained by a combination of metabolism and rapid distribution to tissue/bone.
Authors
- Michael Easton
- Douglas H. Thamm (ORCID: https://orcid.org/0000-0002-8914-7767)
- Uwe Christians (ORCID: https://orcid.org/0000-0001-7297-147X)
- Alexander Karpeisky (ORCID: https://orcid.org/0000-0002-9226-8789)
- Shawn Zinnen (ORCID: https://orcid.org/0000-0003-0426-900X)
- Jost Klawitter (ORCID: https://orcid.org/0000-0002-6413-4820)
- Touraj Shokati
- Kristen B. Farrell (ORCID: https://orcid.org/0000-0003-0476-6575)
Institutions
- MBC Pharma (United States) (US)
- University of Colorado Anschutz Medical Campus (US)
- Colorado State University (US)
Publication Details
- Journal
- Molecules
- Published
- 2025-01-16
- DOI
- https://doi.org/10.3390/molecules30020354
- Citations
- 1
- Primary Topic
- Bone health and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Colorado State University