Detection of low frequency artemisinin resistance mutations, C469Y, P553L and A675V, and fixed antifolate resistance mutations in asymptomatic primary school children in Kenya
The genomic surveillance of asymptomatic school children in Kenya provides an early warning signal of at least 1 of the 3 validated artemisinin resistance mutations circulating in all regions in Western Kenya sampled except Homa Bay and Kisii Counties. These signals in asymptomatic and mixed infections would have been missed without deep sequencing.
Authors
- Regina Kandie
- Robert W. Snow (ORCID: https://orcid.org/0000-0003-3725-6088)
- Collins Okoyo (ORCID: https://orcid.org/0000-0002-2647-1359)
- Lynette Isabella Ochola‐Oyier (ORCID: https://orcid.org/0000-0003-4393-0470)
- Victor Osoti (ORCID: https://orcid.org/0000-0002-0034-1898)
- Paul M. Gichuki (ORCID: https://orcid.org/0000-0001-6558-5538)
- Stella Kepha (ORCID: https://orcid.org/0000-0003-4035-6485)
- Charles Mwandawiro (ORCID: https://orcid.org/0000-0001-8175-3749)
- Kevin Wamae (ORCID: https://orcid.org/0000-0001-7721-5534)
- Leonard Ndwiga (ORCID: https://orcid.org/0009-0004-6825-0783)
- Philip Bejon
- Rosebella Kiplagat
- Kibor Keitany
- Stephen Aricha
Institutions
- Kenya Medical Research Institute (KE)
- University of Oxford (GB)
- Ministry of Health (KE)
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2025-01-16
- DOI
- https://doi.org/10.1186/s12879-025-10462-z
- Citations
- 13
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 24.42
Funders
- Bill and Melinda Gates Foundation
- Wellcome Trust